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    用于治疗非酒精性脂肪性肝炎的PPARα/δ 双重激动剂的设计合成和生物学评价，PK研究、hERG研究和Ames试验通过BOBSport进行

    2023-07-05
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    Nonalcoholic steatohepatitis (NASH) is the advanced subtype of nonalcoholic fatty liver disease (NAFLD) and is becoming a severe global public health problem. PPARα/δ are regarded as potential therapeutic targets for NASH. Herein, researchers report a series of novel triazolone derivatives as PPARα/δ dual agonists.

    The pharmacokinetic studies were conducted by Medicilon.

    The hERG channel inhibition studies were conducted by Medicilon.

    The Ames tests were conducted by Medicilon.

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    Reference:

    Zhiqi Feng, et al. Design, Synthesis, and Biological evalsuation of Triazolone Derivatives as Potent PPARα/δ Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem. 2022 Feb 10;65(3):2571-2592. doi: 10.1021/acs.jmedchem.1c02002. 


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